📢 The LEOPARD challenge workshop will happen live at MICCAI 2024 in Marrakesh, on 6th October in the afternoon session, room Jade.
Clinical Background 🏥¶
Prostate cancer, impacting 1.4 million men annually, is a prevalent malignancy (H. Sung et al., 2021). A substantial number of these individuals undergo prostatectomy as the primary curative treatment. The efficacy of this surgery is assessed, in part, by monitoring the concentration of prostate-specific antigen (PSA) in the bloodstream. While the role of PSA in prostate cancer screening is debatable (W. F. Clark et al., 2018; E. A. M. Heijnsdijk et al., 2018), it serves as a valuable biomarker for postprostatectomy follow-up in patients. Following successful surgery, PSA concentration is typically undetectable (\<0.1 ng/mL) within 4-6 weeks (S. S. Goonewardene et al., 2014). However, approximately 30% of patients experience biochemical recurrence, signifying the resurgence of prostate cancer cells. This recurrence serves as a prognostic indicator for progression to clinical metastases and eventual prostate cancer-related mortality (C.¶
L. Amling, 2014; S. J. Freedland et al., 2005; M. Han et al., 2001; T. Van den Broeck et al., 2001).